Faculty Members

Professor
ISHII Kojiro

Ph.D., Kyoto University, Japan, 1998

Year of birth: 1970
Gender: Male
Affiliation:

- School of Engineering Science
- School of Environmental Science and Engineering
- Life Science and Technology, Department of Engineering, Graduate School of Enginering
Personal web site: http://www.scsci.kochi-tech.ac.jp/ishii/
researchmap： https://researchmap.jp/read0212162
Article from the "Cutting-edge Research and Social Contribution"：
https://www.kochi-tech.ac.jp/english/power/research/dynamic-rearrangement-of-chromosomes-provides-new-possibilities-for-organisms.html

Areas of specialization	Chromosome Biology
Laboratory/research office	Chromosome Function and Regulation Laboratory Chromosomes play a central role in the faithful inheritance of genomes during cell proliferation and progeny formation. However, for some reason, some flexibility is inevitable in the structure and organization of the chromosomes. That flexibility results in the alteration of chromosome structures; this can drive both cancer formation and biological evolution. However, little is known about the regulation of the flexibility and alteration of chromosomes. Our research interest is the elucidation of molecular mechanisms.
Current research topics
Educational background	1995: Master, Kyoto University, Japan 1993: Bachelor, Kyoto University, Japan
Professional background	2008-2018: Associate Professor, Graduate School of Frontier Biosciences, Osaka University 2002-2008: Assistant Professor, Institute of Life Science, Kurume University 1998-2002: Post-Doc, Department of Molecular Biology, Faculty of Science, University of Geneva
Licenses
Academic societies

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Courses

* Courses provided in English are shown with (E) mark

Undergraduate school	Biochemistry・Biophysics Chromosome Engineering Graduation Thesis Biology Experiment Science of Life
Graduate school	Advanced chromosome biology Seminar 1 Seminar 2 Seminar 3 Seminar 4 Individual Work for Graduate Advanced Seminar 1 Advanced Seminar 2

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Research activities

Research papers	Authors: Riku Kuse, Kojiro Ishii Title: Flexible Attachment and Detachment of Centromeres and　Telomeres to and from Chromosomes Journal: Biomolecules, Vol. 13, p. 1016 Year: 2023 Authors: Masatoshi Mutazono, Misato Morita, Chihiro Tsukahara, Madoka Chinen, Shiori Nishioka, Tatsuhiro Yumikake, Kohei Dohke, Misuzu Sakamoto, Takashi Ideue, Jun-ichi Nakayama, Kojiro Ishii, Tokio Tani Title: The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin Journal: PLoS Genetics, Vol. 13, p. e1006606, PLOS Year: 2017 Authors: Yuko Ohno, Yuki Ogiyama, Yoshino Kubota, Takuya Kubo, Kojiro Ishii Title: Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement Journal: Nucleic Acids Research, Vol. 44, pp. 232-244, Oxford University Press Year: 2016 Authors: Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing Journal: Nature Communications, Vol. 7, p. 10393, Nature Publishing Group Year: 2016 Authors: Kazufumi Hosoda, Soichiro Tsuda, Kohmei Kadowaki, Yutaka Nakamura, Tadashi Nakano, Kojiro Ishii Title: Population–reaction model and microbial experimental ecosystems for understanding hierarchical dynamics of ecosystems Journal: Biosystems, Vol. 140, pp. 28-34, Elsevier Year: 2016 Authors: Teppei Kitagawa, Kojiro Ishii, Kojiro Takeda, Tomohiro Matsumoto Title: The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin Journal: Nature Communications, Vol. 5, p. 3597, Nature Publishing Group Year: 2014 Authors: Tadashi Nakano, Kazufumi Hosoda, Yutaka Nakamura, Kojiro Ishii Title: A biologically-inspired intrabody nanonetwork: design considerations Journal: Proceedings of the 8th International Conference on Body Area Networks, pp. 484-487, Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering; ICST Year: 2013 Authors: Yuki Ogiyama, Yuko Ohno, Yoshino Kubota, Kojiro Ishii Title: Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeres Journal: Nature Structural and Molecular Biology, Vol. 20, pp. 1397-1406, Nature Publishing Group Year: 2013 Authors: Kojiro Ishii, Yuki Ogiyama, Yuji Chikashige, Saeko Soejima, Fumie Masuda, Tatsuyuki Kakuma, Yasushi Hiraoka, Kohta Takahashi Title: Heterochromatin integrity affects chromosome reorganization after centromere dysfunction Journal: Science, Vol. 321, pp. 1088-1091, American Association for the Advancement of Science; AAAS Year: 2008 Authors: Shigeaki Saitoh, Kojiro Ishii, Yasuyo Kobayashi, Kohta Takahashi Title: Spindle checkpoint signaling requires the Mis6 kinetochore subcomplex, which interacts with Mad2 and mitotic spindles Journal: Molecular Biology of the Cell, Vol. 16, pp. 3666-3677, American Society of Cell Biology; ASCB Year: 2005 Authors: Kojiro Ishii, Ulrich K. Laemmli Title: Structural and dynamic functions establish chromatin domains Journal: Molecular Cell, Vol. 11, pp. 237-248, Cell Press Year: 2003 Authors: Kojiro Ishii, Ghislaine Arib, Clayton Lin, Griet Van Houwe, Ulrich K. Laemmli Title: Chromatin boundaries in budding yeast: the nuclear pore connection Journal: Cell, Vol. 109, pp. 551-562, Cell Press Year: 2002 Authors: Mitsuhiro Yanagida, Yukiko M. Yamashita, Hisashi Tatebe, Kojiro Ishii, Kazuki Kumada, Yukinobu Nakaseko Title: Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization Journal: Philosophical Transactions of the Royal Society of London B: Biological Sciences, Vol. 354, pp. 1559-1569, The Royal Society Publishing Year: 1999 Authors: Kojiro Ishii, Kazuki Kumada, Takashi Toda, Mitsuhiro Yanagida Title: Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+ Journal: The EMBO Journal, Vol. 15, pp. 6629-6640, EMBO Press Year: 1996 Authors: Hiroyuki Yamano, Kojiro Ishii, Mitsuhiro Yanagida Title: Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation Journal: The EMBO Journal, Vol. 13, pp. 5310-5318, EMBO Press Year: 1994
Invited lectures	Immediate response to chromosomal aneuploidy, Chromosome Dynamics 2019, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 2019 Meiotic stability of newly formed centromeres, The 91st Annual Meeting of the Genetics Society of Japan, 2019 What provides an order to the chromosome configuration?, The 90th Annual Meeting of the Genetics Society of Japan, 2018

Research papers

Authors: Riku Kuse, Kojiro Ishii
Title: Flexible Attachment and Detachment of Centromeres and　Telomeres to and from Chromosomes
Journal: Biomolecules, Vol. 13, p. 1016
Year: 2023
Authors: Masatoshi Mutazono, Misato Morita, Chihiro Tsukahara, Madoka Chinen, Shiori Nishioka, Tatsuhiro Yumikake, Kohei Dohke, Misuzu Sakamoto, Takashi Ideue, Jun-ichi Nakayama, Kojiro Ishii, Tokio Tani
Title: The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin
Journal: PLoS Genetics, Vol. 13, p. e1006606, PLOS
Year: 2017
Authors: Yuko Ohno, Yuki Ogiyama, Yoshino Kubota, Takuya Kubo, Kojiro Ishii
Title: Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement
Journal: Nucleic Acids Research, Vol. 44, pp. 232-244, Oxford University Press
Year: 2016
Authors: Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh
Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing
Journal: Nature Communications, Vol. 7, p. 10393, Nature Publishing Group
Year: 2016
Authors: Kazufumi Hosoda, Soichiro Tsuda, Kohmei Kadowaki, Yutaka Nakamura, Tadashi Nakano, Kojiro Ishii
Title: Population–reaction model and microbial experimental ecosystems for understanding hierarchical dynamics of ecosystems
Journal: Biosystems, Vol. 140, pp. 28-34, Elsevier
Year: 2016
Authors: Teppei Kitagawa, Kojiro Ishii, Kojiro Takeda, Tomohiro Matsumoto
Title: The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin
Journal: Nature Communications, Vol. 5, p. 3597, Nature Publishing Group
Year: 2014
Authors: Tadashi Nakano, Kazufumi Hosoda, Yutaka Nakamura, Kojiro Ishii
Title: A biologically-inspired intrabody nanonetwork: design considerations
Journal: Proceedings of the 8th International Conference on Body Area Networks, pp. 484-487, Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering; ICST
Year: 2013
Authors: Yuki Ogiyama, Yuko Ohno, Yoshino Kubota, Kojiro Ishii
Title: Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeres
Journal: Nature Structural and Molecular Biology, Vol. 20, pp. 1397-1406, Nature Publishing Group
Year: 2013
Authors: Kojiro Ishii, Yuki Ogiyama, Yuji Chikashige, Saeko Soejima, Fumie Masuda, Tatsuyuki Kakuma, Yasushi Hiraoka, Kohta Takahashi
Title: Heterochromatin integrity affects chromosome reorganization after centromere dysfunction
Journal: Science, Vol. 321, pp. 1088-1091, American Association for the Advancement of Science; AAAS
Year: 2008
Authors: Shigeaki Saitoh, Kojiro Ishii, Yasuyo Kobayashi, Kohta Takahashi
Title: Spindle checkpoint signaling requires the Mis6 kinetochore subcomplex, which interacts with Mad2 and mitotic spindles
Journal: Molecular Biology of the Cell, Vol. 16, pp. 3666-3677, American Society of Cell Biology; ASCB
Year: 2005
Authors: Kojiro Ishii, Ulrich K. Laemmli
Title: Structural and dynamic functions establish chromatin domains
Journal: Molecular Cell, Vol. 11, pp. 237-248, Cell Press
Year: 2003
Authors: Kojiro Ishii, Ghislaine Arib, Clayton Lin, Griet Van Houwe, Ulrich K. Laemmli
Title: Chromatin boundaries in budding yeast: the nuclear pore connection
Journal: Cell, Vol. 109, pp. 551-562, Cell Press
Year: 2002
Authors: Mitsuhiro Yanagida, Yukiko M. Yamashita, Hisashi Tatebe, Kojiro Ishii, Kazuki Kumada, Yukinobu Nakaseko
Title: Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization
Journal: Philosophical Transactions of the Royal Society of London B: Biological Sciences, Vol. 354, pp. 1559-1569, The Royal Society Publishing
Year: 1999
Authors: Kojiro Ishii, Kazuki Kumada, Takashi Toda, Mitsuhiro Yanagida
Title: Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+
Journal: The EMBO Journal, Vol. 15, pp. 6629-6640, EMBO Press
Year: 1996
Authors: Hiroyuki Yamano, Kojiro Ishii, Mitsuhiro Yanagida
Title: Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation
Journal: The EMBO Journal, Vol. 13, pp. 5310-5318, EMBO Press
Year: 1994

Invited lectures

Immediate response to chromosomal aneuploidy, Chromosome Dynamics 2019, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 2019
Meiotic stability of newly formed centromeres, The 91st Annual Meeting of the Genetics Society of Japan, 2019
What provides an order to the chromosome configuration?, The 90th Annual Meeting of the Genetics Society of Japan, 2018

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Social activities

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