Faculty Members


ISHII, Kojiro

Ph.D., Kyoto University, Japan, 1998

Areas of specialization Chromosome Biology
Laboratory/research office Chromosome Function and Regulation Laboratory
We are going to elucidate the function of chromosomes and work towards their regulation. Chromosomes are the essential bodies in cell nuclei; they carry the genome, i.e. the blueprint of life. Chromosomes play a central role in the faithful inheritance of genomes during cell proliferation and progeny formation. However, for some reason, some flexibility is inevitable in the structure and organization of the chromosomes. That flexibility results in the alteration of chromosome structures; this can drive both cancer formation and biological evolution. However, little is known about the regulation of the flexibility and alteration of chromosomes. Our research interest is the elucidation of molecular mechanisms.
Current reseach topics
Educational background 1995: Master, Kyoto University, Japan
1993: Bachelor, Kyoto University, Japan
Professional background 2008-2018:  Associate Professor, Graduate School of Frontier Biosciences, Osaka University
2002-2008:  Assistant Professor, Institute of Life Science, Kurume University
1998-2002:  Post-Doc, Department of Molecular Biology, Faculty of Science, University of Geneva
Academic societies

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* Courses provided in English are shown with (E) mark

Undergraduate school
  • Biochemistry・Biophysics
Graduate school
  • Advanced chromosome biology

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Research activities

Research papers
  1. Authors: Masatoshi Mutazono, Misato Morita, Chihiro Tsukahara, Madoka Chinen, Shiori Nishioka, Tatsuhiro Yumikake, Kohei Dohke, Misuzu Sakamoto, Takashi Ideue, Jun-ichi Nakayama, Kojiro Ishii, Tokio Tani
    Title: The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin
    Journal: PLoS Genetics, Vol. 13, p. e1006606, PLOS
    Year: 2017
  2. Authors: Yuko Ohno, Yuki Ogiyama, Yoshino Kubota, Takuya Kubo, Kojiro Ishii
    Title: Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement
    Journal: Nucleic Acids Research, Vol. 44, pp. 232-244, Oxford University Press
    Year: 2016
  3. Authors: Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh
    Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing
    Journal: Nature Communications, Vol. 7, p. 10393, Nature Publishing Group
    Year: 2016
  4. Authors: Kazufumi Hosoda, Soichiro Tsuda, Kohmei Kadowaki, Yutaka Nakamura, Tadashi Nakano, Kojiro Ishii
    Title: Population–reaction model and microbial experimental ecosystems for understanding hierarchical dynamics of ecosystems
    Journal: Biosystems, Vol. 140, pp. 28-34, Elsevier
    Year: 2016
  5. Authors: Teppei Kitagawa, Kojiro Ishii, Kojiro Takeda, Tomohiro Matsumoto
    Title: The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin
    Journal: Nature Communications, Vol. 5, p. 3597, Nature Publishing Group
    Year: 2014
  6. Authors: Tadashi Nakano, Kazufumi Hosoda, Yutaka Nakamura, Kojiro Ishii
    Title: A biologically-inspired intrabody nanonetwork: design considerations
    Journal: Proceedings of the 8th International Conference on Body Area Networks, pp. 484-487, Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering; ICST
    Year: 2013
  7. Authors: Yuki Ogiyama, Yuko Ohno, Yoshino Kubota, Kojiro Ishii
    Title: Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeres
    Journal: Nature Structural and Molecular Biology, Vol. 20, pp. 1397-1406, Nature Publishing Group
    Year: 2013
  8. Authors: Kojiro Ishii, Yuki Ogiyama, Yuji Chikashige, Saeko Soejima, Fumie Masuda, Tatsuyuki Kakuma, Yasushi Hiraoka, Kohta Takahashi
    Title: Heterochromatin integrity affects chromosome reorganization after centromere dysfunction
    Journal: Science, Vol. 321, pp. 1088-1091, American Association for the Advancement of Science; AAAS
    Year: 2008
  9. Authors: Shigeaki Saitoh, Kojiro Ishii, Yasuyo Kobayashi, Kohta Takahashi
    Title: Spindle checkpoint signaling requires the Mis6 kinetochore subcomplex, which interacts with Mad2 and mitotic spindles
    Journal: Molecular Biology of the Cell, Vol. 16, pp. 3666-3677, American Society of Cell Biology; ASCB
    Year: 2005
  10. Authors: Kojiro Ishii, Ulrich K. Laemmli
    Title: Structural and dynamic functions establish chromatin domains
    Journal: Molecular Cell, Vol. 11, pp. 237-248, Cell Press
    Year: 2003
  11. Authors: Kojiro Ishii, Ghislaine Arib, Clayton Lin, Griet Van Houwe, Ulrich K. Laemmli
    Title: Chromatin boundaries in budding yeast: the nuclear pore connection
    Journal: Cell, Vol. 109, pp. 551-562, Cell Press
    Year: 2002
  12. Authors: Mitsuhiro Yanagida, Yukiko M. Yamashita, Hisashi Tatebe, Kojiro Ishii, Kazuki Kumada, Yukinobu Nakaseko
    Title: Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization
    Journal: Philosophical Transactions of the Royal Society of London B: Biological Sciences, Vol. 354, pp. 1559-1569, The Royal Society Publishing
    Year: 1999
  13. Authors: Kojiro Ishii, Kazuki Kumada, Takashi Toda, Mitsuhiro Yanagida
    Title: Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+
    Journal: The EMBO Journal, Vol. 15, pp. 6629-6640, EMBO Press
    Year: 1996
  14. Authors: Hiroyuki Yamano, Kojiro Ishii, Mitsuhiro Yanagida
    Title: Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation
    Journal: The EMBO Journal, Vol. 13, pp. 5310-5318, EMBO Press
    Year: 1994

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Social activities

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